Central Laminated Keratotic Debris

A mixed inflammatory infiltrate.

Central laminated keratotic debris.

Two pyogenic granulomas arising from the wall of an epidermoid cyst on the midback of a 62 year old white man are reported. Keratotic debris ending with. Hypertrophy of the cornea. Hypertrophy of the horny layer of the skin or any disease characterized by it.

Keratin is a fibrous protein found in nails hair and the outer layer of skin. The lesions mainly occur on the scalp back and extensor surface of the legs and are asymmetrically distributed and hyperpigmented with central round or irregularly shaped keratotic plugs. Nail disorders are often due to keratin debris spreading within the nail bed. It usually occurs in the middle aged or elderly and is due to excessive exposure to the sun.

Called also senile or solar keratosis. The dermal connective tissue inflammation and the keratotic debris degenerate to form the basophilic debris which corresponds to the keratotic plug. Presents with pruritic hyperkeratotic and ulcerated nodules and papules with a central keratotic plug mostly located on extensor surface of upper and lower limbs and on the trunk. It is normally hard but can become soft under the nail in the presence of moisture.

Epidermolytic hyperkeratosis a hereditary autosomal dominant form of ichthyosis present at birth. Right side contact us all pages. Multiple keratoacanthomas may be seen in muir torre syndrome associated with sebaceous neoplasms and carcinomas of internal organs. Actinic keratosis a sharply outlined wartlike or keratotic growth which may develop into a cutaneous horn and may become malignant.

Left side donate all pages. Subsequent re epithelization from the adjacent epidermis covers this entire process from the base. And a thinned variably ulcerated epidermis. Keratosis ker ah to sis any horny growth such as a wart or callosity.

Characteristics include generalized redness of the skin and severe. This is exuded from the invagination seen in the fully evolved form of the lesion. Dna polymerase chain reaction pcr and gene sequencing studies performed on the tissue of the microscopic slide and paraffin block for the recently identified ts associated. Histologically each pyogenic granuloma was a polypoid sessile nodule that showed well vascularized granulation tissue.

The absence of hair structure and the presence of inflammatory debris within the invaginations were highly suggestive of kyrle s disease. On histologic examination the tumors are composed of an endophytic exophytic cup shaped squamous epidermal proliferation containing a crater like center filled with laminated keratotic material fig. A recent study described two siblings who developed kd at 2 and 4 years of age and were examined at 7 and 10 years of age respectively. Electron microscopic studies of a follicular lesion showed extracellular viral particles suggestive of a polyomavirus within the central follicular keratotic debris.